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Comporti M, Signorini C, Leoncini S, Buonocore G, Rossi V, Ciccoli L

doi: 10.1007/s43032-024-01452-8, 28

The results obtained demonstrated that the use of ALA (600 mg/day) as an additional therapy to doxorubicin and paclitaxel induces a significant improvement in the peripheral sensory neuropathy grading (according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0) and in the FACT/GOG-Ntx-12 (12-item neurotoxicity questionnaire) total score

PMID: 34937662

This pentadecapeptide demonstrates resistance to degradation in gastric juice, a property that distinguishes it from many therapeutic peptides that require modified administration routes to avoid gastric inactivation